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Related post: LVC, NCI LCMB,NCI BRB, NIAID COOPERATING UNITS (if any) University of Western Australia (S.P. Klinken) LAB/BRANCH Laboratory of Immunopathology Virology and Cellular Immunology Section INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MD 20892 TOTAL MAN-YEARS: 0.5 PROFESSIONAL: 0.5 CHECK APPROPRIATE BOX(ES) □ (a) Human subjects D (a1) Minors □ (a2) Interviews □ (b) Human tissues Q (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.) Analyses of the pathways taken by multipotential progenitor cells in giving rise Buy Asendin Online to diverse elements of the hematopoietic system are poorly understood. The relationship between different pathways of hematopoietic differentiation has been investigated using in vivo transformation of bone marrow cells with retroviruses containing Buy Asendin v- myc alone, v- raf alone or the two oncogenes in a single retrovirus construct. Viruses containing the single oncogenes were found to induce only B cell lineage tumors while the dual-oncogene virus induced cell lines with the ability to differentiate along two different pathways, yielding mature macrophages or mature B cells. These results support earlier suggestions of a close relationship between the myeloid and B cell dif ferentiative pathways. PHS d040 (Rev. 1/84) 9-5 DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOl AI 00138-15 LIP PERIOD COVERED October 1, 1989 to September 30, 1990 TITLE OF PROJECT (80 charactars or lass. Title must fit on one line between the borders.) Viruses and Immune Response PRINCIPAL INVESTIGATOR (List other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation) PI: H. C. Morse, III Chief, LIP, NIAID Others: J. W. Hartley K. L. Holmes T. N. Fredrickson R. M. L. Buller A. Singer Senior Investigator LIP, NIAID Investigator LIP, NIAID Research Microbiologist LIP, NIAID Senior Staff Fellow LVD, NIAID Chief LEI, NCI COOPERATING UNITS (if any) LAB/BRANCH Laboratory of Immunopathology Virology and Cellular Immunology INSTITUTE AND LOCATION NIAID, NIH, Bethesda, MP 20892 TOTAL MAN-YEARS: PROFESSIONAL: CHECK APPROPRIATE BOX(ES) □ (a) Human subjects □ (a1) Minors □ (a2) Interviews □ (b) Human tissues H (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.) Inactive this year. PHS 6040 (Rev. 1(84) 9-6 DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER Z01 AI 00205- 09 LIP PERIOD COVERED October 1. 1989 to September ?n, lQQn TITLE OF PROJECT (80 characters or less. Title must fit on one line between the borders.) Abnormalities of T and B Lymphocytes of Antniinninnp Mi'-p PRINCIPAL INVESTIGATOR (Ust other professional personnel below the Principal Investigator.) (Name, title, laboratory, and institute affiliation) PI: H. C. Morse, III Chief LIP, NIAID Others: W. F. Davidson C. Calkins Visiting Scientist LG, NCI Guest Researcher LIP, NIAID COOPERATING UNITS (if any) Juntendo University, Tokyo, Japan (T. Shirai, K. Okumura) LAB/BRANCH Laboratory of Immunopathology Virology and Cellular Immunology Section INSTITUTE AND LOCATION NIAID, NIH, Bethesda. MP 20892 TOTAL MAN-YEARS:
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